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From350US$ /night
Check-in
14Oct2025Select date
Check-out
15Oct2025Select date
Rooms and Guests2 Guests, 1 Room
Key details

About the Hotel

1528 Locust Street, Saint Louis, Missouri, United States, 63103

The 4-star boutique-style 21C Museum Hotel St Louis Saint Louis is situated right in the centre of Saint Louis approximately a 5-minute walk from World Aquarium. Located in proximity to City Museum, this contemporary hotel features an indoor swimming pool and an à la carte restaurant serving Spanish cuisine.

Location

You'll need 22-minute drive to Lambert airport. The Gateway Arch is a mere 1.9 km from the non-smoking hotel in Saint Louis.

This smoke-free property also gives access to The Boom Boom Room, situated about a 10-minute walk away.

Civic Center Transit Center bus station can be found 650 metres from 21C Museum Hotel St Louis, while Saint Louis Science Center is around 7 km away.

Rooms

There are 173 rooms with an iron and ironing board, and air conditioning. Some of them offer free wireless internet and a flat-screen TV with cable channels as well as tea/coffee making equipment.

Eat & Drink

Idol Wolf, an onsite restaurant, is open for dinner. The lounge bar will set you up nicely for enjoying your stay.

Leisure & Business

At the 21C Museum Saint Louis, guests can also benefit from fitness classes provided at a fitness room. The hotel has a spa salon along with a steam room and a Jacuzzi to relax after a busy day. Business travellers are welcome to use meeting rooms offered on site.

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Select your room type

The hotel provides many room choices—family rooms, doubles, and pet-friendly suites—with breakfast, free cancellation, and special offers
Kamar kembar superior
Max:
2 persons
29 m² 
Bed options:
2 Single beds
Shower
Bathtub
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Kamar queen executive
Max:
2 persons
56 m² 
Bed options:
1 Tempat Tidur Ukuran King
Shower
Bathtub
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Kamar queen deluxe
Max:
2 persons
35 m² 
Bed options:
1 Tempat Tidur Ukuran King
Shower
Bathtub
Check Prices
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Rates & availability calendar

See current prices and availability for your chosen dates!

Local transport and travel tips

Overview of transport options available

City Centre
Saint Louis600 m
Airports
Lambert (STL) 21.8 km
MidAmerica St. Louis/Scott Air Force Base (BLV) 40.8 km
Train
Union Station700 m
Bus
Bus stop200 m

Facilities

Hotels feature amenities designed to keep both you and your pet comfortable

General

  • No smoking on site
  • Free Wi-Fi
  • Safe deposit box
  • 24-hour reception
  • VIP check-in/ -out
  • Pets allowed
  • Rooms/ Facilities for disabled
  • Wheelchair access
  • 24-hour security
  • Luggage storage
  • Locker room
  • Allergy-free rooms
  • Lift
  • ATM/Cash machine
  • Coffee shop
  • Vending machines
  • Smoke detectors
  • Fire extinguishers
  • Key card access

Sports & Fitness

  • Fitness centre
  • Billiard tables
  • Yoga class

Services

  • Valet parking
  • Room service
  • Housekeeping
  • Laundry
  • Dry cleaning
  • Welcome drink

Dining

  • Restaurant
  • Bar/ Lounge area
  • Special diet menus

Business

  • Business centre
  • Meeting/ Banquet facilities

Children

  • Board games
  • Game room

Facilities for people with disabilities

  • Toilet for disabled

Spa & Leisure

  • Indoor swimming pool
  • Leisure/ TV room
  • Spa & wellness centre
  • Steam room
  • Jacuzzi
  • Massage

Room features

  • Wi-Fi in rooms
  • Air conditioning
  • Heating
  • Soundproofed rooms
  • Sitting area
  • Terrace
  • Garden furniture
  • Ironing facilities

Bathroom

  • Free toiletries

Media

  • Flat-screen TV
  • Direct dial telephone
  • AM/FM alarm clock
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Hotel location

1528 Locust Street, Saint Louis, Missouri, United States, 63103
Map view
1528 Locust Street, Saint Louis, Missouri, United States, 63103
Nearby
Museum
City Museum
520 m
Museum
Campbell House Museum
90 m
Church
Christ Church Cathedral
430 m
1315 Chestnut St
Soldiers Memorial Military Museum
590 m
Aquarium
World Aquarium
400 m
Church
Centenary United Methodist Church
190 m
Night club
The Boom Boom Room
280 m
13th and Locust
Lucas Garden Park
350 m
Restaurants
The Last Kitchen
360 m
1501 Washington Ave Inside The Last Hotel
Red Oak Biscuits
310 m
1330 Washington Ave
Nara Cafe and Hookah Lounge
310 m
1326 Washington Ave
Flannery's
380 m
1324 Washington Ave
Rooftop Cafe at City Museum
400 m
701 N 15th St Fl 11
Lucas Park Grille
440 m
1234 Washington Avenue
Rosalita's Cantina
480 m
1235 Washington Avenue
Blondie's Coffee
450 m
1301 Washington Ave
Imo's Pizza
410 m
1828 Washington Ave
Papa John's Pizza
610 m
201 N Tucker Blvd Ste E
Bootleggin' BBQ
650 m
1933 Washington Ave
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Check Rates
Check-in
14Oct2025Select date
Check-out
15Oct2025Select date
Rooms and Guests2 Guests, 1 Room